Agonists of the TRAIL death receptor DR5 sensitize intestinal stem cells to chemotherapy-induced cell death and trigger gastrointestinal toxicity

The combination of TRAIL death receptor agonists and radiochemotherapy to treat advanced cancers continues to be investigated in clinical trials. We previously showed that normal cells with a functional DNA damage response (DDR) upregulate the expression of death inducing receptor DR5/TRAILR2/TNFRSF...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Finnberg, Niklas K., Gokare, Prashanth, Navaraj, Arunasalam, Lang Kuhs, Krystle A., Cerniglia, George, Yagita, Hideo, Takeda, Kazuyoshi, Motoyama, Noboru, El-Deiry, Wafik S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001853/
https://ncbi.nlm.nih.gov/pubmed/26609054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2759
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