Global intron retention mediated gene regulation during CD4(+) T cell activation

T cell activation is a well-established model for studying cellular responses to exogenous stimulation. Using strand-specific RNA-seq, we observed that intron retention is prevalent in polyadenylated transcripts in resting CD4(+) T cells and is significantly reduced upon T cell activation. Several l...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Ni, Ting, Yang, Wenjing, Han, Miao, Zhang, Yubo, Shen, Ting, Nie, Hongbo, Zhou, Zhihui, Dai, Yalei, Yang, Yanqin, Liu, Poching, Cui, Kairong, Zeng, Zhouhao, Tian, Yi, Zhou, Bin, Wei, Gang, Zhao, Keji, Peng, Weiqun, Zhu, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001615/
https://ncbi.nlm.nih.gov/pubmed/27369383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw591
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