Knockdown of DNA methyltransferase 3a alters gene expression and inhibits function of embryonic cardiomyocytes

We previously found that in utero caffeine exposure causes down-regulation of DNA methyltransferases (DNMTs) in embryonic heart and results in impaired cardiac function in adulthood. To assess the role of DNMTs in these events, we investigated the effects of reduced DNMT expression on embryonic card...

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Bibliographic Details
Published in:FASEB J
Main Authors: Fang, Xiefan, Poulsen, Ryan R., Wang-Hu, John, Shi, Olivia, Calvo, Nicholas S., Simmons, Chelsey S., Rivkees, Scott A., Wendler, Christopher C.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001511/
https://ncbi.nlm.nih.gov/pubmed/27306334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600346R
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