Resolvin D2 decreases TLR4 expression to mediate resolution in human monocytes

TLRs are critical for innate immunity, but excessive activation can lead to tissue damage and disease. Specialized proresolving mediators (SPMs), including resolvin D2 (RvD2), promote the active resolution of inflammation. How SPMs regulate early LPS signaling, including activation of TLR4, is unkno...

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Опубликовано в: :FASEB J
Главные авторы: Croasdell, Amanda, Sime, Patricia J., Phipps, Richard P.
Формат: Artigo
Язык:Inglês
Опубликовано: Federation of American Societies for Experimental Biology 2016
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Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001508/
https://ncbi.nlm.nih.gov/pubmed/27256622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600375R
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