Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division

Caspase-1 is a key player during the initiation of pro-inflammatory innate immune responses, activating pro-IL-1β in so-called inflammasomes. A subset of patients with recurrent febrile episodes and systemic inflammation of unknown origin harbor mutations in CASP1 encoding caspase-1. CASP1 variants...

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Vydáno v:J Biol Chem
Hlavní autoři: Stein, Robert, Kapplusch, Franz, Heymann, Michael Christian, Russ, Susanne, Staroske, Wolfgang, Hedrich, Christian Michael, Rösen-Wolff, Angela, Hofmann, Sigrun Ruth
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000087/
https://ncbi.nlm.nih.gov/pubmed/27402835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.718668
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