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Targeted Reconstitution of Cytokine Activity upon Antigen Binding using Split Cytokine Antibody Fusion Proteins

The targeted assembly of antibody products upon antigen binding represents a novel strategy for the reconstitution of potent therapeutic activity at the site of disease, sparing healthy tissues. We demonstrate that interleukin-12, a heterodimeric pro-inflammatory cytokine consisting of the disulfide...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Venetz, Dario, Koovely, Danil, Weder, Bruce, Neri, Dario
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5000063/
https://ncbi.nlm.nih.gov/pubmed/27402834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.737734
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