Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function

Dysfunctional cellular lipid metabolism contributes to common chronic human diseases, including type 2 diabetes, obesity, fatty liver disease and diabetic cardiomyopathy. How cells balance lipid storage and mitochondrial oxidative capacity is poorly understood. Here we identify the lipid droplet pro...

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Pubblicato in:Nat Commun
Autori principali: Gallardo-Montejano, Violeta I., Saxena, Geetu, Kusminski, Christine M., Yang, Chaofeng, McAfee, John L., Hahner, Lisa, Hoch, Kathleen, Dubinsky, William, Narkar, Vihang A., Bickel, Perry E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999519/
https://ncbi.nlm.nih.gov/pubmed/27554864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12723
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