Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function

Dysfunctional cellular lipid metabolism contributes to common chronic human diseases, including type 2 diabetes, obesity, fatty liver disease and diabetic cardiomyopathy. How cells balance lipid storage and mitochondrial oxidative capacity is poorly understood. Here we identify the lipid droplet pro...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Gallardo-Montejano, Violeta I., Saxena, Geetu, Kusminski, Christine M., Yang, Chaofeng, McAfee, John L., Hahner, Lisa, Hoch, Kathleen, Dubinsky, William, Narkar, Vihang A., Bickel, Perry E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999519/
https://ncbi.nlm.nih.gov/pubmed/27554864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12723
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky