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Lack of Influence of Substrate on Ligand Interaction with the Human Multidrug and Toxin Extruder, MATE1

Multidrug and toxin extruder (MATE) 1 plays a central role in mediating renal secretion of organic cations, a structurally diverse collection of compounds that includes ∼40% of prescribed drugs. Because inhibition of transport activity of other multidrug transporters, including the organic cation tr...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Martínez-Guerrero, Lucy J., Morales, Mark, Ekins, Sean, Wright, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4998666/
https://ncbi.nlm.nih.gov/pubmed/27418674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.105056
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