Simvastatin up-regulates adenosine deaminase and suppresses osteopontin expression in COPD patients through an IL-13-dependent mechanism

BACKGROUND: Adenosine deaminase (ADA) and osteopontin (OPN) may play opposing roles in the pathogenesis of COPD. Deficiency of ADA results in enhanced adenosine signaling which up-regulates OPN expression. Although statins suppress OPN in cancer cells, little is known about their effects on ADA and...

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Vydáno v:Respir Res
Hlavní autoři: Maneechotesuwan, Kittipong, Kasetsinsombat, Kanda, Wongkajornsilp, Adisak, Barnes, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997725/
https://ncbi.nlm.nih.gov/pubmed/27557561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-016-0424-6
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