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The novel asymmetric entry intermediate of a picornavirus captured with nanodiscs

Many nonenveloped viruses engage host receptors that initiate capsid conformational changes necessary for genome release. Structural studies on the mechanisms of picornavirus entry have relied on in vitro approaches of virus incubated at high temperatures or with excess receptor molecules to trigger...

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Publicat a:Sci Adv
Autors principals: Lee, Hyunwook, Shingler, Kristin L., Organtini, Lindsey J., Ashley, Robert E., Makhov, Alexander M., Conway, James F., Hafenstein, Susan
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996645/
https://ncbi.nlm.nih.gov/pubmed/27574701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1501929
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