Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis

Branching morphogenesis in the mammary gland is achieved by the migration of epithelial cells through a microenvironment consisting of stromal cells and extracellular matrix (ECM). Here we show that galectin-1 (Gal-1), an endogenous lectin that recognizes glycans bearing N-acetyllactosamine (LacNAc)...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Bhat, Ramray, Belardi, Brian, Mori, Hidetoshi, Kuo, Peiwen, Tam, Andrew, Hines, William C., Le, Quynh-Thu, Bertozzi, Carolyn R., Bissell, Mina J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995945/
https://ncbi.nlm.nih.gov/pubmed/27496330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609135113
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