Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury

Macrophages are key regulators of fibrosis development and resolution. Elucidating the mechanisms by which they mediate this process is crucial for establishing their therapeutic potential. Here, we use experimental models of liver fibrosis to show that deficiency of the scavenger receptor, stabilin...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Rantakari, Pia, Patten, Daniel A., Valtonen, Joona, Karikoski, Marika, Gerke, Heidi, Dawes, Harriet, Laurila, Juha, Ohlmeier, Steffen, Elima, Kati, Hübscher, Stefan G., Weston, Chris J., Jalkanen, Sirpa, Adams, David H., Salmi, Marko, Shetty, Shishir
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995933/
https://ncbi.nlm.nih.gov/pubmed/27474165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604780113
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