Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory

Alterations in cAMP signaling are thought to contribute to neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4 (PDE4) family, which contains >25 different isoforms, play a key role in determining spatial cAMP degradation so as to orchestrate compartment...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Havekes, Robbert, Park, Alan J., Tolentino, Rosa E., Bruinenberg, Vibeke M., Tudor, Jennifer C., Lee, Yool, Hansen, Rolf T., Guercio, Leonardo A., Linton, Edward, Neves-Zaph, Susana R., Meerlo, Peter, Baillie, George S., Houslay, Miles D., Abel, Ted
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995304/
https://ncbi.nlm.nih.gov/pubmed/27559174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0248-16.2016
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