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Should tissue structure suppress or amplify selection to minimize cancer risk?

BACKGROUND: It has been frequently argued that tissues evolved to suppress the accumulation of growth enhancing cancer inducing mutations. A prominent example is the hierarchical structure of tissues with high cell turnover, where a small number of tissue specific stem cells produces a large number...

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Podrobná bibliografie
Vydáno v:Biol Direct
Hlavní autoři: Hindersin, Laura, Werner, Benjamin, Dingli, David, Traulsen, Arne
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994303/
https://ncbi.nlm.nih.gov/pubmed/27549612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13062-016-0140-7
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