Downregulation of p70S6K Enhances Cell Sensitivity to Rapamycin in Esophageal Squamous Cell Carcinoma

It has been demonstrated that mTOR/p70S6K pathway was abnormally activated in many cancers and rapamycin and its analogs can restrain tumor growth through inhibiting this pathway, but some tumors including esophageal squamous cell carcinoma (ESCC) appear to be insensitive to rapamycin in recent stud...

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Опубликовано в: :J Immunol Res
Главные авторы: Lu, Zhaoming, Peng, Kezheng, Wang, Ning, Liu, Hong-Min, Hou, Guiqin
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi Publishing Corporation 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993948/
https://ncbi.nlm.nih.gov/pubmed/27595116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/7828916
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