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Diacylglycerol kinase-α controls T cell polarity by shaping diacylglycerol accumulation at the immune synapse
Polarization of the T cell microtubule-organizing center (MTOC) to the immunological synapse maintains the specificity of effector responses by enabling directional secretion toward the antigen-presenting cell. MTOC reorientation is guided by a sharp gradient of diacylglycerol that is centered at th...
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| Publicado no: | Sci Signal |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4993625/ https://ncbi.nlm.nih.gov/pubmed/25161317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005287 |
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