Styrene maleic acid-encapsulated paclitaxel micelles: antitumor activity and toxicity studies following oral administration in a murine orthotopic colon cancer model

Oral administration of paclitaxel (PTX), a broad spectrum anticancer agent, is challenged by its low uptake due to its poor bioavailability, efflux through P-glycoprotein, and gastrointestinal toxicity. We synthesized PTX nanomicelles using poly(styrene-co-maleic acid) (SMA). Oral administration of...

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Publicat a:Int J Nanomedicine
Autors principals: Parayath, Neha N, Nehoff, Hayley, Norton, Samuel E, Highton, Andrew J, Taurin, Sebastien, Kemp, Roslyn A, Greish, Khaled
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2016
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993259/
https://ncbi.nlm.nih.gov/pubmed/27574427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S110251
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