Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy

Each year, millions of African children receive praziquantel (PZQ) by mass drug administration (MDA) to treat schistosomiasis at a standard single dose of 40 mg/kg of body weight, a direct extrapolation from studies of adults. A higher dose of 60 mg/kg is also acceptable for refractory cases. We con...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Bustinduy, Amaya L., Waterhouse, David, de Sousa-Figueiredo, Jose C., Roberts, Stephen A., Atuhaire, Aaron, Van Dam, Govert J., Corstjens, Paul L. A. M., Scott, Janet T., Stanton, Michelle C., Kabatereine, Narcis B., Ward, Stephen, Hope, William W., Stothard, J. Russell
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992966/
https://ncbi.nlm.nih.gov/pubmed/27507822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00227-16
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