Cutaneous tissue damage induces long-lasting nociceptive sensitization and regulation of cellular stress- and nerve injury-associated genes in sensory neurons

Tissue damage is one of the major etiological factors in the emergence of chronic/persistent pain, although mechanisms remain enigmatic. Using incision of the back skin of adult rats as a model for tissue damage, we observed sensitization in a nociceptive reflex enduring to 28 days post-incision (DP...

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Pubblicato in:Exp Neurol
Autori principali: Rau, Kristofer K., Hill, Caitlin E., Harrison, Benjamin J., Venkat, Gayathri, Koenig, Heidi M., Cook, Sarah B., Rabchevsky, Alexander G., Taylor, Bradley K., Hai, Tsonwin, Petruska, Jeffrey C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992590/
https://ncbi.nlm.nih.gov/pubmed/27264359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2016.06.002
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