Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling

Cancer-associated fibroblasts (CAFs), the most common constituent of the tumor stoma, are known to promote tumor initiation, progression and metastasis. However, the mechanism of how cancer cells transform normal fibroblasts (NFs) into CAFs is largely unknown. In this study, we determined the contri...

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Publicat a:PLoS Genet
Autors principals: Shen, Hua, Yu, Xiaobo, Yang, Fengming, Zhang, Zhihua, Shen, Jianxin, Sun, Jin, Choksi, Swati, Jitkaew, Siriporn, Shu, Yongqian
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991802/
https://ncbi.nlm.nih.gov/pubmed/27541266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006244
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