Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling

Cancer-associated fibroblasts (CAFs), the most common constituent of the tumor stoma, are known to promote tumor initiation, progression and metastasis. However, the mechanism of how cancer cells transform normal fibroblasts (NFs) into CAFs is largely unknown. In this study, we determined the contri...

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Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: Shen, Hua, Yu, Xiaobo, Yang, Fengming, Zhang, Zhihua, Shen, Jianxin, Sun, Jin, Choksi, Swati, Jitkaew, Siriporn, Shu, Yongqian
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991802/
https://ncbi.nlm.nih.gov/pubmed/27541266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006244
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