Genetic and Pharmacological Intervention of the p75NTR Pathway Alters Morphological and Behavioural Recovery Following Traumatic Brain Injury in Mice

PRIMARY OBJECTIVE: Neurotrophin levels are elevated after TBI yet there is minimal regeneration. It was hypothesized that the pro-neurotrophin/p75NTR pathway is induced more than the mature neurotrophin/Trk pathway and that interfering with p75 signaling improves recovery following TBI. RESEARCH DES...

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Detalhes bibliográficos
Publicado no:Stem Cell Res
Main Authors: Alder, Janet, Fujioka, Wendy, Giarratana, Anna, Wissocki, Jenna, Thakkar, Keya, Vuong, Phung, Patel, Bijal, Chakraborty, Trisha, Elsabeh, Rami, Parikh, Ankit, Girn, Hartaj S., Crockett, David, Thakker-Varia, Smita
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991619/
https://ncbi.nlm.nih.gov/pubmed/24747217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2014.03.005
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