Ubiquitination of the transcription factor IRF-3 activates RIPA, the apoptotic pathway that protects mice from viral pathogenesis

The transcription factor IRF-3 mediates cellular antiviral response by inducing the expression of interferon and other antiviral proteins. In RNA-virus infected cells, IRF-3’s transcriptional activation is triggered primarily by RIG-I-like receptors (RLR), which can also activate the RLR-induced IRF...

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Vydáno v:Immunity
Hlavní autoři: Chattopadhyay, Saurabh, Kuzmanovic, Teodora, Zhang, Ying, Wetzel, Jaime L., Sen, Ganes C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991351/
https://ncbi.nlm.nih.gov/pubmed/27178468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.04.009
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