Molecular dynamics-based refinement and validation for sub-5 Å cryo-electron microscopy maps

Two structure determination methods, based on the molecular dynamics flexible fitting (MDFF) paradigm, are presented that resolve sub-5 Å cryo-electron microscopy (EM) maps with either single structures or ensembles of such structures. The methods, denoted cascade MDFF and resolution exchange MDFF,...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Singharoy, Abhishek, Teo, Ivan, McGreevy, Ryan, Stone, John E, Zhao, Jianhua, Schulten, Klaus
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2016
Teme:
Biophysics and Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990421/
https://ncbi.nlm.nih.gov/pubmed/27383269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16105
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