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Linagliptin reduces effects of ET-1 and TLR2-mediated cerebrovascular hyperreactivity in diabetes

AIMS: The anti-hyperglycemic agent linagliptin, a dipeptidyl peptidase-4 inhibitor, has been shown to reduce inflammation and improve endothelial cell function. In this study, we hypothesized that DPP-IV inhibition with linagliptin would improve impaired cerebral blood flow in diabetic rats through...

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Bibliografiske detaljer
Udgivet i:Life Sci
Main Authors: Hardigan, Trevor, Abdul, Yasir, Ergul, Adviye
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988948/
https://ncbi.nlm.nih.gov/pubmed/26898123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2016.02.067
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