Prolonged Exposure of Primary Human Muscle Cells to Plasma Fatty Acids Associated with Obese Phenotype Induces Persistent Suppression of Muscle Mitochondrial ATP Synthase β Subunit

Our previous studies show reduced abundance of the β-subunit of mitochondrial H+-ATP synthase (β-F1-ATPase) in skeletal muscle of obese individuals. The β-F1-ATPase forms the catalytic core of the ATP synthase, and it is critical for ATP production in muscle. The mechanism(s) impairing β-F1-ATPase m...

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Bibliographic Details
Published in:PLoS One
Main Authors: Tran, Lee, Hanavan, Paul D., Campbell, Latoya E., De Filippis, Elena, Lake, Douglas F., Coletta, Dawn K., Roust, Lori R., Mandarino, Lawrence J., Carroll, Chad C., Katsanos, Christos S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988792/
https://ncbi.nlm.nih.gov/pubmed/27532680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160057
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