Decoding the Regulatory Landscape of Ageing in Musculoskeletal Engineered Tissues Using Genome-Wide DNA Methylation and RNASeq

Mesenchymal stem cells (MSC) are capable of multipotent differentiation into connective tissues and as such are an attractive source for autologous cell-based regenerative medicine and tissue engineering. Epigenetic mechanisms, like DNA methylation, contribute to the changes in gene expression in ag...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Peffers, Mandy Jayne, Goljanek-Whysall, Katarzyna, Collins, John, Fang, Yongxiang, Rushton, Michael, Loughlin, John, Proctor, Carole, Clegg, Peter David
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988628/
https://ncbi.nlm.nih.gov/pubmed/27533049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160517
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