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Computational investigation of cold denaturation in the Trp-cage miniprotein
The functional native states of globular proteins become unstable at low temperatures, resulting in cold unfolding and impairment of normal biological function. Fundamental understanding of this phenomenon is essential to rationalizing the evolution of freeze-tolerant organisms and developing improv...
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Publicado no: | Proc Natl Acad Sci U S A |
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Main Authors: | , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4987839/ https://ncbi.nlm.nih.gov/pubmed/27457961 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607500113 |
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