Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination

The “canonical” proteasomal degradation signal is a substrate-anchored polyubiquitin chain. However, a handful of proteins were shown to be targeted following monoubiquitination. In this study, we established—in both human and yeast cells—a systematic approach for the identification of monoubiquitin...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Braten, Ori, Livneh, Ido, Ziv, Tamar, Admon, Arie, Kehat, Izhak, Caspi, Lilac H., Gonen, Hedva, Bercovich, Beatrice, Godzik, Adam, Jahandideh, Samad, Jaroszewski, Lukasz, Sommer, Thomas, Kwon, Yong Tae, Guharoy, Mainak, Tompa, Peter, Ciechanover, Aaron
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987823/
https://ncbi.nlm.nih.gov/pubmed/27385826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608644113
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