Targeted nanoconjugate co-delivering siRNA and tyrosine kinase inhibitor to KRAS mutant NSCLC dissociates GAB1-SHP2 post oncogene knockdown

A tri-block nanoparticle (TBN) comprising of an enzymatically cleavable porous gelatin nanocore encapsulated with gefitinib (tyrosine kinase inhibitor (TKI)) and surface functionalized with cetuximab-siRNA conjugate has been synthesized. Targeted delivery of siRNA to undruggable KRAS mutated non-sma...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Srikar, R., Suresh, Dhananjay, Zambre, Ajit, Taylor, Kristen, Chapman, Sarah, Leevy, Matthew, Upendran, Anandhi, Kannan, Raghuraman
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987653/
https://ncbi.nlm.nih.gov/pubmed/27530552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30245
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