Identification of Siglec-1 null individuals infected with HIV-1

Siglec-1/CD169 is a myeloid-cell surface receptor critical for HIV-1 capture and infection of bystander target cells. To dissect the role of SIGLEC1 in natura, we scan a large population genetic database and identify a loss-of-function variant (Glu88Ter) that is found in ∼1% of healthy people. Exome...

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Vydáno v:Nat Commun
Hlavní autoři: Martinez-Picado, Javier, McLaren, Paul J., Erkizia, Itziar, Martin, Maureen P., Benet, Susana, Rotger, Margalida, Dalmau, Judith, Ouchi, Dan, Wolinsky, Steven M., Penugonda, Sudhir, Günthard, Huldrych F., Fellay, Jacques, Carrington, Mary, Izquierdo-Useros, Nuria, Telenti, Amalio
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987525/
https://ncbi.nlm.nih.gov/pubmed/27510803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12412
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