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OX40(+) regulatory T cells in cutaneous squamous cell carcinoma suppress effector T cell responses and associate with metastatic potential

PURPOSE: Cutaneous squamous cell carcinoma (cSCC) is the most common human cancer with metastatic potential. Despite T cells accumulating around cSCCs, these tumors continue to grow and persist. To investigate reasons for failure of T cells to mount a protective response in cSCC, we focused on regul...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Lai, Chester, August, Suzannah, Albibas, Amel, Behar, Ramnik, Cho, Shin-Young, Polak, Marta E, Theaker, Jeff, MacLeod, Amanda S, French, Ruth R, Glennie, Martin J, Al-Shamkhani, Aymen, Healy, Eugene
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987192/
https://ncbi.nlm.nih.gov/pubmed/27034329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2614
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