Superior therapeutic efficacy of nab-paclitaxel over cremophor-based paclitaxel in locally advanced and metastatic models of human pancreatic cancer

BACKGROUND: Albumin-bound paclitaxel (nab-paclitaxel, nab-PTX) plus gemcitabine (GEM) combination has demonstrated efficient antitumour activity and statistically significant overall survival of patients with metastatic pancreatic ductal adenocarcinoma (PDAC) compared with GEM monotherapy. This regi...

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Veröffentlicht in:Br J Cancer
Hauptverfasser: Rajeshkumar, N V, Yabuuchi, Shinichi, Pai, Shweta G, Tong, Zeen, Hou, Shihe, Bateman, Scott, Pierce, Daniel W, Heise, Carla, Von Hoff, Daniel D, Maitra, Anirban, Hidalgo, Manuel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Translational Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985357/
https://ncbi.nlm.nih.gov/pubmed/27441498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.215
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