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α-SNAP regulates dynamic, on-site assembly and calcium selectivity of Orai1 channels
Orai1 forms a highly calcium-selective pore of the calcium release activated channel, and α-SNAP is necessary for its function. Here we show that α-SNAP regulates on-site assembly of Orai1 dimers into calcium-selective multimers. We find that Orai1 is a dimer in resting primary mouse embryonic fibro...
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| Publicado no: | Mol Biol Cell |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4985256/ https://ncbi.nlm.nih.gov/pubmed/27335124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-03-0163 |
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