Comparative Single-Cell Analysis of Different E. coli Expression Systems during Microfluidic Cultivation

Recombinant protein production is mostly realized with large-scale cultivations and monitored at the level of the entire population. Detailed knowledge of cell-to-cell variations with respect to cellular growth and product formation is limited, even though phenotypic heterogeneity may distinctly ham...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Binder, Dennis, Probst, Christopher, Grünberger, Alexander, Hilgers, Fabienne, Loeschcke, Anita, Jaeger, Karl-Erich, Kohlheyer, Dietrich, Drepper, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985164/
https://ncbi.nlm.nih.gov/pubmed/27525986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160711
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