p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies

Mallory-Denk bodies (MDBs) are hepatocytic protein aggregates found in steatohepatitis and several other chronic liver diseases as well as hepatocellular carcinoma. MDBs are mainly composed of phosphorylated keratins and stress protein p62/Sequestosome-1 (p62), which is a common component of cytopla...

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Veröffentlicht in:PLoS One
Hauptverfasser: Lahiri, Pooja, Schmidt, Volker, Smole, Claudia, Kufferath, Iris, Denk, Helmut, Strnad, Pavel, Rülicke, Thomas, Fröhlich, Leopold F., Zatloukal, Kurt
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985067/
https://ncbi.nlm.nih.gov/pubmed/27526095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161083
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