Transcription-induced DNA supercoiling: New roles of intranucleosomal DNA loops in DNA repair and transcription

RNA polymerase II (Pol II) transcription through chromatin is accompanied by formation of small intranucleosomal DNA loops. Pol II captured within a small loop drives accumulation of DNA supercoiling, facilitating further transcription. DNA breaks relieve supercoiling and induce Pol II arrest, allow...

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Enregistré dans:
Détails bibliographiques
Publié dans:Transcription
Auteurs principaux: Gerasimova, N. S., Pestov, N. A., Kulaeva, O. I., Clark, D. J., Studitsky, V. M.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2016
Sujets:
Point-of-View
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984681/
https://ncbi.nlm.nih.gov/pubmed/27115204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541264.2016.1182240
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