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Control of glioblastoma tumorigenesis by feed-forward cytokine signaling
EGFRvIII-STAT3 signaling is important in glioblastoma pathogenesis. Here, we identified the cytokine receptor OSMR as a direct target gene of the transcription factor STAT3 in mouse astrocytes and human brain tumor stem cells (BTSCs). We found that OSMR functioned as an essential co-receptor for EGF...
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Publicado en: | Nat Neurosci |
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Autores principales: | , , , , , , , , , , , , , , |
Formato: | Artigo |
Lenguaje: | Inglês |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4984527/ https://ncbi.nlm.nih.gov/pubmed/27110918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4295 |
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