Control of glioblastoma tumorigenesis by feed-forward cytokine signaling

EGFRvIII-STAT3 signaling is important in glioblastoma pathogenesis. Here, we identified the cytokine receptor OSMR as a direct target gene of the transcription factor STAT3 in mouse astrocytes and human brain tumor stem cells (BTSCs). We found that OSMR functioned as an essential co-receptor for EGF...

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Publié dans:Nat Neurosci
Auteurs principaux: Jahani-Asl, Arezu, Yin, Hang, Soleimani, Vahab D, Haque, Takrima, Luchman, H Artee, Chang, Natasha C, Sincennes, Marie-Claude, Puram, Sidharth V, Scott, Andrew M, Lorimer, Ian A J, Perkins, Theodore J, Ligon, Keith L, Weiss, Samuel, Rudnicki, Michael A, Bonni, Azad
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984527/
https://ncbi.nlm.nih.gov/pubmed/27110918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4295
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