Association of CpG island methylator phenotype and EREG/AREG methylation and expression in colorectal cancer

BACKGROUND: High EREG and AREG expression, and left-sided primary tumours are associated with superior efficacy of anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer (CRC), but a unifying explanation of these findings is lacking. METHODS: RNA-seq, gene expression ar...

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Bibliografiske detaljer
Udgivet i:Br J Cancer
Main Authors: Lee, Michael S, McGuffey, Elizabeth J, Morris, Jeffrey S, Manyam, Ganiraju, Baladandayuthapani, Veerabahdran, Wei, Wei, Morris, Van K, Overman, Michael J, Maru, Dipen M, Jiang, Zhi-Qin, Hamilton, Stanley R, Kopetz, Scott
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984478/
https://ncbi.nlm.nih.gov/pubmed/27272216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2016.87
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