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CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer

Immune checkpoint blockade has shown significant therapeutic efficacy in melanoma and other solid tumors, but results in ovarian cancer have been limited. With evidence that tumor immunogenicity modulates the response to checkpoint blockade, and data indicating that BRCA-deficient ovarian cancers ex...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Higuchi, Tomoe, Flies, Dallas B., Marjon, Nicole A., Mantia-Smaldone, Gina, Ronner, Lukas, Gimotty, Phyllis A., Adams, Sarah F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984269/
https://ncbi.nlm.nih.gov/pubmed/26138335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0044
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