CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer

Immune checkpoint blockade has shown significant therapeutic efficacy in melanoma and other solid tumors, but results in ovarian cancer have been limited. With evidence that tumor immunogenicity modulates the response to checkpoint blockade, and data indicating that BRCA-deficient ovarian cancers ex...

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Bibliographic Details
Published in:Cancer Immunol Res
Main Authors: Higuchi, Tomoe, Flies, Dallas B., Marjon, Nicole A., Mantia-Smaldone, Gina, Ronner, Lukas, Gimotty, Phyllis A., Adams, Sarah F.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984269/
https://ncbi.nlm.nih.gov/pubmed/26138335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0044
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