Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors

[Image: see text] ATG4B or autophagin-1 is a cysteine protease that cleaves ATG8 family proteins. ATG4B plays essential roles in the autophagosome formation and the autophagy pathway. Herein we disclose the design and structural modifications of a series of fluoromethylketone (FMK)-based peptidomime...

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Publicado en:ACS Med Chem Lett
Autores principales: Qiu, Zongxing, Kuhn, Bernd, Aebi, Johannes, Lin, Xianfeng, Ding, Haiyuan, Zhou, Zheng, Xu, Zhiheng, Xu, Danqing, Han, Li, Liu, Cheng, Qiu, Hongxia, Zhang, Yuxia, Haap, Wolfgang, Riemer, Claus, Stahl, Martin, Qin, Ning, Shen, Hong C., Tang, Guozhi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2016
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983731/
https://ncbi.nlm.nih.gov/pubmed/27563406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00208
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