Microtubule-Dependent Mitochondria Alignment Regulates Calcium Release in Response to Nanomechanical Stimulus in Heart Myocytes

Arrhythmogenesis during heart failure is a major clinical problem. Regional electrical gradients produce arrhythmias, and cellular ionic transmembrane gradients are its originators. We investigated whether the nanoscale mechanosensitive properties of cardiomyocytes from failing hearts have a bearing...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Miragoli, Michele, Sanchez-Alonso, Jose L., Bhargava, Anamika, Wright, Peter T., Sikkel, Markus, Schobesberger, Sophie, Diakonov, Ivan, Novak, Pavel, Castaldi, Alessandra, Cattaneo, Paola, Lyon, Alexander R., Lab, Max J., Gorelik, Julia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983655/
https://ncbi.nlm.nih.gov/pubmed/26725114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.014
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