Serum starvation-induced cell cycle synchronization stimulated mouse rDNA transcription reactivation during somatic cell reprogramming into iPSCs

BACKGROUND: rDNA, the genes encoding ribosomal RNA (rRNA), is highly demanded for ribosome production and protein synthesis in growing cells such as pluripotent stem cells. rDNA transcription activity varies between cell types, metabolism conditions, and specific environmental challenges. Embryonic...

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Bibliografiske detaljer
Udgivet i:Stem Cell Res Ther
Main Authors: Zhao, Qiaoshi, Wu, Yanshuang, Shan, Zhiyan, Bai, Guangyu, Wang, Zhendong, Hu, Jing, Liu, Li, Li, Tong, Shen, Jingling, Lei, Lei
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981958/
https://ncbi.nlm.nih.gov/pubmed/27515169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-016-0369-1
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