Exendin-4 enhances the differentiation of Wharton’s jelly mesenchymal stem cells into insulin-producing cells through activation of various β-cell markers

BACKGROUND: Diabetes mellitus is a devastating metabolic disease. Generation of insulin-producing cells (IPCs) from stem cells, especially from Wharton’s jelly mesenchymal stem cells (WJ-MSCs), has sparked much interest recently. Exendin-4 has several beneficial effects on MSCs and β cells. However,...

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Vydáno v:Stem Cell Res Ther
Hlavní autoři: Kassem, Dina H., Kamal, Mohamed M., El-Kholy, Abd El-Latif G., El-Mesallamy, Hala O.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981957/
https://ncbi.nlm.nih.gov/pubmed/27515427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-016-0374-4
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