Novel pH-Sensitive Cyclic Peptides

A series of cyclic peptides containing a number of tryptophan (W) and glutamic acid (E) residues were synthesized and evaluated as pH-sensitive agents for targeting of acidic tissue and pH-dependent cytoplasmic delivery of molecules. Biophysical studies revealed the molecular mechanism of peptides a...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Weerakkody, Dhammika, Moshnikova, Anna, El-Sayed, Naglaa Salem, Adochite, Ramona-Cosmina, Slaybaugh, Gregory, Golijanin, Jovana, Tiwari, Rakesh K., Andreev, Oleg A., Parang, Keykavous, Reshetnyak, Yana K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981864/
https://ncbi.nlm.nih.gov/pubmed/27515582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31322
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