Dissociable effects of the prodrug phendimetrazine and its metabolite phenmetrazine at dopamine transporters

Phendimetrazine (PDM) is a clinically available anorectic and a candidate pharmacotherapy for cocaine addiction. PDM has been hypothesized to function as a prodrug that requires metabolism to the amphetamine-like monoamine transporter substrate phenmetrazine (PM) to produce its pharmacological effec...

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Pubblicato in:Sci Rep
Autori principali: Solis, Ernesto, Suyama, Julie A., Lazenka, Matthew F., DeFelice, Louis J., Negus, S. Stevens, Blough, Bruce E., Banks, Matthew L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981850/
https://ncbi.nlm.nih.gov/pubmed/27514281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31385
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