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BRD4 Phosphorylation Regulates HPV E2-Mediated Viral Transcription, Origin Replication and Cellular MMP-9 Expression
Post-translational modification can modulate protein conformation and alter binding partner recruitment within promoter regulatory regions. Here, we find that bromodomain-containing protein 4 (BRD4), a transcription cofactor and chromatin regulator, uses a phosphorylation-induced switch mechanism to...
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| Опубликовано в: : | Cell Rep |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4981545/ https://ncbi.nlm.nih.gov/pubmed/27477287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.001 |
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