Reduction of c-Fos via Overexpression of miR-34a Results in Enhancement of TNF- Production by LPS in Neutrophils from Myelodysplastic Syndrome Patients

Although increased TNF-α has been considered to cause ineffective hematopoiesis in myelodysplastic syndromes (MDS), the mechanisms of TNF-α elevation are not known. We recently found that c-Fos mRNA stabilization under translation-inhibiting stimuli was impaired in MDS-derived neutrophilic granulocy...

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Udgivet i:PLoS One
Main Authors: Shikama, Yayoi, Cao, Meiwan, Ono, Tomoyuki, Feng, Xiaomin, Noji, Hideyoshi, Kimura, Hideo, Ogawa, Kazuei, Suzuki, Yuko, Ikeda, Kazuhiko, Takeishi, Yasuchika, Kimura, Junko
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981319/
https://ncbi.nlm.nih.gov/pubmed/27513856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158527
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