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Improved oral bioavailability of poorly water-soluble glimepiride by utilizing microemulsion technique
The objective of this work was to prepare an oil/water glimepiride (GM) microemulsion (ME) for oral administration to improve its solubility and enhance its bioavailability. Based on a solubility study, pseudoternary phase diagrams, and Box–Behnken design, the oil/water GMME formulation was optimize...
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| Gepubliceerd in: | Int J Nanomedicine |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Dove Medical Press
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4981171/ https://ncbi.nlm.nih.gov/pubmed/27540291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S105419 |
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