TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye

An intractable challenge in glaucoma treatment has been to identify druggable targets within the conventional aqueous humor outflow pathway, which is thought to be regulated/dysregulated by elusive mechanosensitive protein(s). Here, biochemical and functional analyses localized the putative mechanos...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ryskamp, Daniel A., Frye, Amber M., Phuong, Tam T. T., Yarishkin, Oleg, Jo, Andrew O., Xu, Yong, Lakk, Monika, Iuso, Anthony, Redmon, Sarah N., Ambati, Balamurali, Hageman, Gregory, Prestwich, Glenn D., Torrejon, Karen Y., Križaj, David
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980693/
https://ncbi.nlm.nih.gov/pubmed/27510430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30583
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